logo
ResearchBunny Logo
Combined KRAS G12C and SOS1 inhibition enhances and extends the anti-tumor response in KRAS G12C -driven cancers by addressing intrinsic and acquired resistance

Medicine and Health

Combined KRAS G12C and SOS1 inhibition enhances and extends the anti-tumor response in KRAS G12C -driven cancers by addressing intrinsic and acquired resistance

V. Thatikonda, H. Lu, et al.

This research conducted by Venu Thatikonda and colleagues explores a promising therapeutic strategy in targeting KRAS G12C with the SOS1-KRAS interaction inhibitor, BI-3406. The combination shows a superior anti-tumor response, overcoming resistance mechanisms in lung and colorectal cancer models.

00:00
00:00
Playback language: English
Citation Metrics
Citations
0
Influential Citations
0
Reference Count
0

Note: The citation metrics presented here have been sourced from Semantic Scholar and OpenAlex.

Related Publications

Explore these studies to deepen your understanding of the subject.

The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer
Medicine and Health

The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer

N. Ghaddar, S. Wang, et al.

Overcoming resistance to BRAF V600E inhibition in melanoma by deciphering and targeting personalized protein network alterations
Medicine and Health

Overcoming resistance to BRAF V600E inhibition in melanoma by deciphering and targeting personalized protein network alterations

S. Vasudevan, E. Flashner-abramson, et al.

Rapid subduction initiation and magmatism in the Western Pacific driven by internal vertical forces
Earth Sciences

Rapid subduction initiation and magmatism in the Western Pacific driven by internal vertical forces

B. Maunder, J. Prytulak, et al.

Dopamine release and dopamine-related gene expression in the amygdala are modulated by the gastrin-releasing peptide in opposite directions during stress-enhanced fear learning and extinction
Psychology

Dopamine release and dopamine-related gene expression in the amygdala are modulated by the gastrin-releasing peptide in opposite directions during stress-enhanced fear learning and extinction

Y. Morishita, I. Fuentes, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny