Medicine and Health

Overcoming resistance to BRAF V600E inhibition in melanoma by deciphering and targeting personalized protein network alterations

S. Vasudevan, E. Flashner-abramson, et al.

This groundbreaking study by S. Vasudevan, E. Flashner-Abramson, and colleagues unveils a personalized approach to combating BRAF V600E melanoma relapses. By utilizing high-resolution signaling signatures to craft individualized drug combinations, the research demonstrates remarkable efficacy compared to standard therapies, offering new hope for patients facing drug resistance.

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Abstract

BRAF V600E melanoma patients, despite initial response to anti-BRAF V600E therapy, often relapse due to drug resistance. This study designs individualized melanoma combination treatments based on personalized network alterations using an information-theoretic approach. High-resolution patient-specific altered signaling signatures are computed, consisting of co-expressed subnetworks. Smart, personalized drug combinations (often FDA-approved) are designed based on these signatures, showing superior efficacy in vitro and in vivo compared to standard therapies. This approach is highly selective, and broadly applicable for designing patient-specific anti-melanoma drug combinations.

Publisher

npj Precision Oncology

Published On

Jun 10, 2021

Authors

S. Vasudevan, E. Flashner-Abramson, Heba Alkhaiti, Sangita Roy Chowdhury, I. A. Adejumobi, D. Vlienski, S. Stefansky, A. M. Rubinstein, N. Kravchenko-Balasha

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