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Abstract
This systematic review and meta-analysis investigated the clinical severity of different SARS-CoV-2 variants during mass COVID-19 vaccination. Thirteen studies were included, focusing on four clinical severity metrics: confirmed case-hospitalization risk (cCHR), confirmed case-fatality risk (cCFR), hospitalization-fatality risk (HFR), and hospitalization-ICU risk (HIR). The Delta variant showed the highest severity across all metrics, while Omicron showed the lowest. Adults over 65 exhibited higher severity levels than other age groups.
Publisher
Viruses
Published On
Sep 26, 2023
Authors
Zhilu Yuan, Zengyang Shao, Lijia Ma, Renzhong Guo
Tags
SARS-CoV-2
clinical severity
COVID-19
Delta variant
Omicron variant
vaccination
meta-analysis

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