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Clinical Severity of SARS-CoV-2 Variants during COVID-19 Vaccination: A Systematic Review and Meta-Analysis

Medicine and Health

Clinical Severity of SARS-CoV-2 Variants during COVID-19 Vaccination: A Systematic Review and Meta-Analysis

Z. Yuan, Z. Shao, et al.

Discover the critical findings of a systematic review and meta-analysis investigating the clinical severity of SARS-CoV-2 variants during mass vaccination. Researchers Zhilu Yuan, Zengyang Shao, Lijia Ma, and Renzhong Guo reveal that the Delta variant poses the highest severity while Omicron shows the lowest, particularly affecting adults over 65. Uncover these insights!

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Playback language: English
Abstract
This systematic review and meta-analysis investigated the clinical severity of different SARS-CoV-2 variants during mass COVID-19 vaccination. Thirteen studies were included, focusing on four clinical severity metrics: confirmed case-hospitalization risk (cCHR), confirmed case-fatality risk (cCFR), hospitalization-fatality risk (HFR), and hospitalization-ICU risk (HIR). The Delta variant showed the highest severity across all metrics, while Omicron showed the lowest. Adults over 65 exhibited higher severity levels than other age groups.
Publisher
Viruses
Published On
Sep 26, 2023
Authors
Zhilu Yuan, Zengyang Shao, Lijia Ma, Renzhong Guo
Tags
SARS-CoV-2
clinical severity
COVID-19
Delta variant
Omicron variant
vaccination
meta-analysis

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