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Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance

Psychology

Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance

A. L. Eagle, C. E. Manning, et al.

Discover how chronic stress impacts mood disorders in groundbreaking research by Andrew L. Eagle and collaborators. This study reveals that the transcription factor ΔFosB plays a crucial role in regulating ventral hippocampus glutamatergic neurons, offering insights into the molecular mechanisms behind depression and anxiety. Dive into a journey that could unlock new therapeutic targets for these prevalent conditions!

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Playback language: English
Abstract
Chronic stress is a major risk factor for mood disorders. This study uses circuit-specific gene editing to demonstrate that the transcription factor ΔFosB regulates the activity of ventral hippocampus glutamatergic neurons, influencing behavioral responses to stress. The findings establish molecular, cellular, and circuit-level mechanisms for depression- and anxiety-like behaviors and identify potential therapeutic targets for depression.
Publisher
Nature Communications
Published On
Sep 08, 2020
Authors
Andrew L. Eagle, Claire E. Manning, Elizabeth S. Williams, Ryan M. Bastle, Paula A. Gajewski, Amber Garrison, Alexis J. Wirtz, Seda Akguen, Katie Brandel-Ankrapp, Wilson Endege, Frederick M. Boyce, Yoshinori N. Ohnishi, Michelle Mazei-Robison, Ian Maze, Rachel L. Neve, Alfred J. Robison
Tags
chronic stress
mood disorders
ΔFosB
ventral hippocampus
glutamatergic neurons
depression
anxiety

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