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Characterization of anti-AAV2 neutralizing antibody levels in sheep prior to and following intravitreal AAV2.7m8 injection
Veterinary ScienceGene Therapy

Characterization of anti-AAV2 neutralizing antibody levels in sheep prior to and following intravitreal AAV2.7m8 injection

M. Ross, K. Sade, et al.

This groundbreaking study explores the humoral immune response to AAV2.7m8 delivery in sheep, revealing that pre-existing anti-AAV2 neutralizing antibodies heighten the risk of ocular inflammation post-surgery. Conducted by a team of experts including Maya Ross, Kareen Sade, and Alexey Obolensky, this research evaluates the implications for managing AAV-mediated ocular gene therapies.... show more
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