Medicine and Health

Casirivimab + imdevimab accelerates symptom resolution linked to improved COVID-19 outcomes across susceptible antibody and risk profiles

D. Li, M. Xu, et al.

This study by Dateng Li and colleagues investigates how the combination of casirivimab and imdevimab (CAS + IMD) remarkably speeds up the resolution of COVID-19 symptoms in high-risk outpatients. With significant benefits observed in reducing hospitalization and mortality, particularly for critical symptoms like cough and fever, the research opens new avenues for improving COVID-19 outcomes.

00:00

Playback language: English

Index

Abstract

This study investigated the impact of casirivimab and imdevimab (CAS + IMD) treatment on COVID-19 symptom resolution in high-risk outpatients. The analysis revealed that CAS + IMD significantly accelerated the resolution of 17 out of 23 symptoms compared to placebo, particularly in patients lacking robust early antibody responses. Resolution of five key symptoms (dyspnea, cough, fever, fatigue, loss of appetite) independently correlated with reduced hospitalization and death. Treatment benefits were observed across various risk profiles and even in those with late seroconversion. These findings highlight the potential of CAS + IMD to improve COVID-19 outcomes by accelerating symptom resolution.

Publisher

Scientific Reports

Published On

Aug 23, 2023

Authors

Dateng Li, Meng Xu, Andrea T Hooper, Diana Rofail, Kusha A Mohammadi, Yiziying Chen, Shazia Ali, Thomas Norton, David M Weinreich, Bret J Musser, Jennifer D Hamilton, Gregory P Geba

Related Publications

Explore these studies to deepen your understanding of the subject.

Health and Fitness

Multidisciplinary approach to COVID-19 risk communication: a framework and tool for individual and regional risk assessment

R. R. Parajuli, B. Mishra, et al.

Medicine and Health

Risk factors for and pregnancy outcomes after SARS-CoV-2 in pregnancy according to disease severity: A nationwide cohort study with validation of the SARS-CoV-2 diagnosis of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG)

A. J. M. Aabakke, T. G. Petersen, et al.

Biology

The Breadth of the Neutralizing Antibody Response to Original SARS-CoV-2 Infection is Linked to the Presence of Long COVID Symptoms

A. M. Buck, A. N. Deitchman, et al.

Psychology

Who do we trust and how do we cope with COVID-19? A mixed-methods sequential exploratory approach to understanding supportive messages across 35 cultures

A. K. Y. Au, J. C. K. Ng, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny