Medicine and Health

Casirivimab + imdevimab accelerates symptom resolution linked to improved COVID-19 outcomes across susceptible antibody and risk profiles

D. Li, M. Xu, et al.

This study by Dateng Li and colleagues investigates how the combination of casirivimab and imdevimab (CAS + IMD) remarkably speeds up the resolution of COVID-19 symptoms in high-risk outpatients. With significant benefits observed in reducing hospitalization and mortality, particularly for critical symptoms like cough and fever, the research opens new avenues for improving COVID-19 outcomes.

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Abstract

This study investigated the impact of casirivimab and imdevimab (CAS + IMD) treatment on COVID-19 symptom resolution in high-risk outpatients. The analysis revealed that CAS + IMD significantly accelerated the resolution of 17 out of 23 symptoms compared to placebo, particularly in patients lacking robust early antibody responses. Resolution of five key symptoms (dyspnea, cough, fever, fatigue, loss of appetite) independently correlated with reduced hospitalization and death. Treatment benefits were observed across various risk profiles and even in those with late seroconversion. These findings highlight the potential of CAS + IMD to improve COVID-19 outcomes by accelerating symptom resolution.

Publisher

Scientific Reports

Published On

Aug 23, 2023

Authors

Dateng Li, Meng Xu, Andrea T Hooper, Diana Rofail, Kusha A Mohammadi, Yiziying Chen, Shazia Ali, Thomas Norton, David M Weinreich, Bret J Musser, Jennifer D Hamilton, Gregory P Geba

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