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Mathematical modeling insights into improving CAR T cell therapy for solid tumors with bystander effects

Medicine and Health

Mathematical modeling insights into improving CAR T cell therapy for solid tumors with bystander effects

E. Kara, T. L. Jackson, et al.

This cutting-edge research explores the development of a mathematical model to enhance the efficacy of CAR T cell therapy against solid tumors, overcoming challenges like antigen heterogeneity and bystander effects. Conducted by a team of experts, this study reveals that merely increasing CAR T cell dosage is not enough; boosting bystander cell cytotoxicity promises significant improvements in patient outcomes.

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Playback language: English
Abstract
Chimeric Antigen Receptor T cell (CAR T cell) therapy has shown remarkable success in hematological malignancies but limited efficacy against solid tumors due to challenges like antigen heterogeneity and poor infiltration. This study develops a mathematical model of CAR T cell therapy for solid tumors, considering antigen heterogeneity and bystander effects (antigen spreading). Using in vivo data, the model simulates virtual patients to understand bystander killing and explore strategies for enhancement. Results suggest that increasing CAR T cell dosage alone is insufficient; enhancing bystander cell cytotoxicity significantly improves outcomes.
Publisher
npj Systems Biology and Applications
Published On
Sep 28, 2024
Authors
Erdi Kara, Trachette L. Jackson, Chartese Jones, Rockford Sison, Reginald L. McGee II
Tags
CAR T cell therapy
solid tumors
antigen heterogeneity
bystander effects
mathematical model
cytotoxicity

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