This paper proposes a strategy to delineate regional high seismic risk zones at a fine resolution and with high confidence. Using seismic hazard and loss estimation for Mw 7.5 scenarios on the Jiaocheng fault (China), the study shows that the delineated high-risk zone, comprising ~7% of the land area, accounts for ~85% of the total financial loss. Prioritizing mitigation efforts in such zones is recommended for better disaster risk reduction.