Biology

Biosynthesis of strychnine

B. Hong, D. Grzech, et al.

Explore the groundbreaking research conducted by Benke Hong and colleagues on the biosynthetic pathway of strychnine, brucine, and diaboline. Their work in *Nicotiana benthamiana* reveals exciting possibilities for metabolic engineering of these complex compounds.

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Abstract

This paper reports the biosynthetic pathway of strychnine, brucine, and diaboline. The authors successfully recapitulated the biosynthesis of these compounds in *Nicotiana benthamiana* from an upstream intermediate, demonstrating the potential for harnessing this complex class of compounds through metabolic engineering.

Publisher

Nature

Published On

Jul 21, 2022

Authors

Benke Hong, Dagny Grzech, Lorenzo Caputi, Prashant Sonawane, Carlos E. Rodríguez López, Mohamed Omar Kamileen, Néstor J. Hernández Lozada, Veit Grabe, Sarah E. O’Connor

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