This paper reports the biosynthetic pathway of strychnine, brucine, and diaboline. The authors successfully recapitulated the biosynthesis of these compounds in *Nicotiana benthamiana* from an upstream intermediate, demonstrating the potential for harnessing this complex class of compounds through metabolic engineering.
Publisher
Nature
Published On
Jul 21, 2022
Authors
Benke Hong, Dagny Grzech, Lorenzo Caputi, Prashant Sonawane, Carlos E. Rodríguez López, Mohamed Omar Kamileen, Néstor J. Hernández Lozada, Veit Grabe, Sarah E. O’Connor
Tags
biosynthesis
strychnine
brucine
diaboline
metabolic engineering
Nicotiana benthamiana
natural products
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