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Harnessing phosphonate antibiotics argolaphos biosynthesis enables a synthetic biology-based green synthesis of glyphosate

Agriculture

Harnessing phosphonate antibiotics argolaphos biosynthesis enables a synthetic biology-based green synthesis of glyphosate

L. Chu, X. Luo, et al.

This groundbreaking research explores the enhanced production of aminomethylphosphonate (AMP), a vital intermediate in the biosynthesis of the argolaphos antibiotic. Conducted by Leixia Chu and colleagues, the study showcases a sustainable approach to glyphosate production that reduces hazardous waste.

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Playback language: English
Abstract
Glyphosate, a widely used herbicide, is produced through processes involving hazards and toxic wastes. This research characterizes genes for aminomethylphosphonate (AMP) production, an intermediate in argolaphos antibiotic biosynthesis. A synthetic biology strategy enhances AMP production in *Streptomyces lividans*, achieving a 500-fold improvement. An efficient chemical process converts AMP to glyphosate, offering a greener alternative.
Publisher
NATURE COMMUNICATIONS
Published On
Apr 01, 2022
Authors
Leixia Chu, Xiaoxia Luo, Taoting Zhu, Yingying Cao, Lili Zhang, Zixin Deng, Jiangtao Gao
Tags
glyphosate
aminomethylphosphonate
Streptomyces lividans
synthetic biology
sustainable production
herbicide
antibiotic biosynthesis

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