Chemistry

Bioinspired light-driven chloride pump with helical porphyrin channels

C. Li, Y. Zhai, et al.

Discover the innovative world of artificial ion pumping with this study on a light-driven chloride pump inspired by halorhodopsin. Conducted by Chao Li and colleagues, this research showcases a remarkable helical porphyrin channel array that mimics natural processes and offers exciting applications in optogenetics!

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Abstract

Halorhodopsin, a light-driven chloride pump, utilizes photonic energy to drive chloride ions across biological membranes. Inspired by halorhodopsin, this study demonstrates an artificial light-driven chloride pump using a helical porphyrin channel array. The helical porphyrin channels are formed by a porphyrin-core star block copolymer, and defects are repaired by doping porphyrins. The repaired channel exhibits light-driven Cl⁻ migration against a 3-fold concentration gradient, showcasing ion pumping behavior. This bio-inspired pump offers prospects for designing responsive ion channel systems and high-performance optogenetics.

Publisher

Nature Communications

Published On

Jan 27, 2024

Authors

Chao Li, Yi Zhai, Heming Jiang, Siqi Li, Pengxiang Liu, Longcheng Gao, Lei Jiang

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