This study investigates the relationship between childhood sexual abuse (CSA), auditory hallucinations (AH), sex, and limbic gray matter volume (GMV) in a transdiagnostic sample of individuals with psychotic disorders. The researchers found that individuals with psychotic disorders and AH reported significantly higher levels of CSA compared to those without AH and healthy controls. This effect was particularly pronounced among females with AH. Furthermore, greater CSA severity in patients correlated with larger left amygdala GMV, even after controlling for various factors. The study suggests that females with AH and a history of CSA may represent a unique subgroup and highlights the potential neurobiological mechanisms linking CSA, amygdala alterations, and AH.
Publisher
Schizophrenia
Published On
Dec 30, 2022
Authors
Zachary B. Millman, Melissa Hwang, Valerie J. Sydnor, Benjamin E. Reid, Joshua E. Goldenberg, Jessica N. Talero, Sylvain Bouix, Martha E. Shenton, Dost Öngür, Ann K. Shinn
Tags
childhood sexual abuse
auditory hallucinations
limbic gray matter volume
psychotic disorders
neurobiological mechanisms
females
amygdala
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