Biology

ATP induces folding of ALS-causing C71G-hPFN1 and nascent hSOD1

J. Kang, L. Lim, et al.

Discover how ATP transforms C71G-hPFN1 into a fully folded state and induces nascent hSOD1 into a mix of folded and unfolded states. This exciting research by Jian Kang, Liangzhong Lim, and Jianxing Song sheds light on the potential role of polyphosphates as primordial chaperones and offers valuable insights into age-related familial ALS onset.

00:00

Playback language: English

Index

Abstract

ALS-causing C71G-hPFN1 exists in folded and unfolded states, while nascent hSOD1 is unfolded. This study uses NMR to show that ATP converts C71G-hPFN1 completely into its folded state (1:2 ratio), and induces nascent hSOD1 into a mixture of folded and unfolded states (1:8 ratio). ATP's triphosphate group is responsible for this effect, but free triphosphate causes aggregation. The mechanism involves ATP enhancing the intrinsic folding capacity of the proteins. The findings suggest a role for polyphosphates as primordial chaperones and offer insight into age-related familial ALS onset.

Publisher

Communications Chemistry

Published On

Jun 15, 2023

Authors

Jian Kang, Liangzhong Lim, Jianxing Song

Related Publications

Explore these studies to deepen your understanding of the subject.

Business

Effect of digital literacy on social entrepreneurial intentions and nascent behaviours among students and practitioners in mass communication

C. Y. Ip

Biology

Gut microbiota determines the social behavior of mice and induces metabolic and inflammatory changes in their adipose tissue

O. Agranyomi, S. Meininger-mordechaï, et al.

Medicine and Health

L-valine is a powerful stimulator of GLP-1 secretion in rodents and stimulates secretion through ATP-sensitive potassium channels and voltage-gated calcium channels

I. M. Modvig, M. M. Smits, et al.

Medicine and Health

S1PR1 induces metabolic reprogramming of ceramide in vascular endothelial cells, affecting hepatocellular carcinoma angiogenesis and progression

X. Wang, Z. Qiu, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny