Atomically dispersed golds on degradable zero-valent copper nanocubes augment oxygen driven Fenton-like reaction for effective orthotopic tumor therapy

This study introduces a novel approach to fabricate atomically dispersed Au on degradable zero-valent Cu nanocubes for tumor treatment. The galvanic replacement method, controlling HAuCl₄ addition, yielded various AuₓCuᵧ ratios. X-ray absorption near-edge spectroscopy confirmed the predominant zero-valence state of Au and Cu. The Au₀.₀₂Cu₀.₉₈ composition showed enhanced ·OH generation via O₂ → H₂O₂ → ·OH, with degradable release of Cu⁺ and Cu²⁺ facilitating oxygen reduction and Fenton-like reactions. Simulations supported the catalytic role of Au single atoms in boosting zero-valent copper's activity. Importantly, Au₀.₀₂Cu₀.₉₈ demonstrated biodegradability and renal clearance.

Liu-Chun Wang, Li-Chan Chang, Wen-Qi Chen, Yi-Hsin Chien, Po-Ya Chang, Chih-Wen Pao, Yin-Fen Liu, Hwo-Shuenn Sheu, Wen-Pin Su, Chen-Hao Yeh, Chen-Sheng Yeh