Veterinary Science

Assessment of African swine fever vaccine candidate ASFV-G-AMGF in a reversion to virulence study

P. Deutschmann, J. Forth, et al.

This study explores the safety of the promising ASF vaccine candidate ASFV-G-AMGF, revealing that despite some transient fever and increased virus replication in a forced animal passaging study, the animals remained healthy. Conducted by a team of experts including Paul Deutschmann and Sandra Blome, it emphasizes the importance of thorough safety assessments for live ASF vaccines.

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Abstract

This study assessed the safety of the African swine fever (ASF) vaccine candidate ASFV-G-AMGF through an in vivo reversion to virulence study. Forced animal passaging led to a virus variant with transient fever and increased replication/shedding, but animals remained healthy. Genomic changes involved deletions and reorganizations in terminal regions, not affecting the recombination site. The study highlights the need for in-depth safety characterization of live ASF vaccines, suggesting further studies on long-term effects and transmission before benefit-risk analysis.

Publisher

npj Vaccines

Published On

May 29, 2023

Authors

Paul Deutschmann, Jan-Hendrik Forth, Julia Sehl-Ewert, Tessa Carrau, Elisenda Viaplana, Jose Carlos Mancera, Alicia Urniza, Martin Beer, Sandra Blome

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