This open-label, pragmatic clinical trial randomized pregnant and postpartum women in Nigeria to usual care or AI-guided screening for left ventricular systolic dysfunction (LVSD). AI-guided screening, using a digital stethoscope and 12-lead ECG with AI predictions, significantly improved LVSD diagnosis compared to usual care (digital stethoscope: odds ratio 2.12, P=0.032; 12-lead ECG: odds ratio 1.75, P=0.125). No serious adverse events were reported. AI-guided screening using a digital stethoscope improved the diagnosis of pregnancy-related cardiomyopathy.

Demilade A. Adedinsewo, Andrea Carolina Morales-Lara, Bosede B. Afolabi, Oyewole A. Kushimo, Amam C. Mbakwem, Kehinde F. Ibiyemi, James Ayodele Ogunmodede, Hadijat Olaide Raji, Sadiq H. Ringim, Abdullahi A. Habib, Sabiu M. Hamza, Okechukwu S. Ogah, Gbolahan Obajimi, Olugbenga Oluseun Saanu, Olusoji E. Jagun, Francisca O. Inofomoh, Temitope Adeolu, Kamilu M. Karaye, Sule A. Gaya, Isiaka Alfa, Cynthia Yohanna, K. L. Venkatachalam, Jennifer Dugan, Xiaoxi Yao, Hanna J. Sledge, Patrick W. Johnson, Mikolaj A. Wieczorek, Zachi I. Attia, Sabrina D. Phillips, Mohamad H. Yamani, Yvonne Butler Tobah, Carl H. Rose, Emily E. Sharpe, Francisco Lopez-Jimenez, Paul A. Friedman, Peter A. Noseworthy, Rickey E. Carter