Medicine and Health

Antibiotic-Loaded Coatings to Reduce Fracture-Related Infections: Retrospective Case Series of Patients with Increased Infectious Risk

D. D. Meo, G. Cera, et al.

This study by De Meo et al. investigates the efficacy of antibiotic-coated implants in preventing fracture-related infections in high-risk patients, reporting a remarkable reduction in infection rates. Only one case of FRI was observed among 37 patients, showcasing the promise of local antibiotic prophylaxis.

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Abstract

This retrospective observational study evaluated the efficacy and safety of antibiotic-coated implants in preventing fracture-related infections (FRIs) in high-risk patients. 37 patients with upper and lower limb fractures treated with internal fixation or prosthetic replacements using gentamicin-coated nails (CN) and/or antibiotic-loaded hydrogel (ALH) were included. Only one FRI (2.94%) occurred. Local antibiotic prophylaxis reduced FRI incidence compared to the estimated preoperative risk. ALH offers antibiotic choice but less uniform application than CN.

Publisher

Antibiotics

Published On

Feb 01, 2023

Authors

Daniele De Meo, Gianluca Cera, Roberta Pica, Fabiano Perfetti, Paolo Martini, Beatrice Perciballi, Giancarlo Ceccarelli, Pietro Persiani, Ciro Villani

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