This study investigated the association between DNA methylation and Parkinson's disease (PD) risk using a blood-based methylome-wide association study (MWAS) meta-analysis of two independent cohorts. Two epigenome-wide significant associations were identified, one involving cg068690548 on chromosome 4. Hypermethylation at cg068690548 was linked to down-regulation of the SLC7A11 gene, suggesting an environmental influence rather than genetic factors. SLC7A11 encodes a cystine-glutamate antiporter crucial for glutathione regulation, a known target of the environmental neurotoxin β-methylamino-L-alanine (BMAA). These findings implicate SLC7A11 as a potential biological target in PD.
Publisher
Nature Communications
Published On
Mar 06, 2020
Authors
Costanza L. Vallerga, Futao Zhang, Javed Fowdar, Allan F. McRae, Ting Qi, Marta F. Nabais, Qian Zhang, Irfahan Kassam, Anjalk K. Henders, Leanne Wallace, Grant Montgomery, Yu-Hsuan Chuang, Steve Horvath, Beate Ritz, Glenda Halliday, Ian Hickie, John B. Kwok, John Pearson, Toni Pitcher, Martin Kennedy, Steven R. Bentley, Peter A. Silburn, Jian Yang, Naomi R. Wray, Simon J.G. Lewis, John Dalrymple-Alford, George D. Mellick, Peter M. Visscher, Jacob Gratten
Tags
DNA methylation
Parkinson's disease
SLC7A11
epigenetics
environmental factors
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