Medicine and Health

An outcome-driven threshold for pulse pressure amplification

Q. Huang, D. An, et al.

Did you know that a pulse pressure amplification (PPA) of less than 1.3 could significantly increase the risk of cardiovascular events? This groundbreaking research by Qi-Fang Huang and colleagues analyzed data from over 5,600 participants and reveals crucial insights, particularly for women aged 30–60. Don't miss these vital findings that could reshape our understanding of heart health!

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Abstract

Pulse pressure amplification (PPA), the brachial-to-aortic pulse pressure ratio, decreases with age and cardiovascular risk factors. This individual-participant meta-analysis (n = 5608) aimed to define an outcome-driven threshold for PPA. Over 4.1 years, 255 and 109 participants experienced cardiovascular or coronary endpoints, respectively. A PPA threshold of <1.3 was identified, with higher hazard ratios for both endpoints (HRs: 1.54 and 2.45, respectively). Findings were replicated in a test dataset. HRs were notably higher in individuals <60 years. A PPA <1.3 was a significant risk factor, particularly underestimated in women aged 30–60 years.

Publisher

Hypertension Research

Published On

Jul 22, 2024

Authors

Qi-Fang Huang, De-Wei An, Lucas S. Aparicio, Yi-Bang Cheng, Fang-Fei Wei, Yu-Ling Yu, Chang-Sheng Sheng, Wen-Yi Yang, Teemu J. Niiranen, José Boggia, Katarzyna Stolarz-Skrzypek, Valérie Tikhonoff, Natasza Gilis-Malinowska, Wiktoria Wojciechowska, Edoardo Casiglia, Krzysztof Narkiewicz, Jan Filipovský, Kalina Kawecka-Jaszcz, Tim S. Nawrot, Ji-Guang Wang, Yan Li, Jan A. Staessen

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