logo
ResearchBunny Logo
An outcome-driven threshold for pulse pressure amplification

Medicine and Health

An outcome-driven threshold for pulse pressure amplification

Q. Huang, D. An, et al.

Did you know that a pulse pressure amplification (PPA) of less than 1.3 could significantly increase the risk of cardiovascular events? This groundbreaking research by Qi-Fang Huang and colleagues analyzed data from over 5,600 participants and reveals crucial insights, particularly for women aged 30–60. Don't miss these vital findings that could reshape our understanding of heart health!

00:00
00:00
Playback language: English
Abstract
Pulse pressure amplification (PPA), the brachial-to-aortic pulse pressure ratio, decreases with age and cardiovascular risk factors. This individual-participant meta-analysis (n = 5608) aimed to define an outcome-driven threshold for PPA. Over 4.1 years, 255 and 109 participants experienced cardiovascular or coronary endpoints, respectively. A PPA threshold of <1.3 was identified, with higher hazard ratios for both endpoints (HRs: 1.54 and 2.45, respectively). Findings were replicated in a test dataset. HRs were notably higher in individuals <60 years. A PPA <1.3 was a significant risk factor, particularly underestimated in women aged 30–60 years.
Publisher
Hypertension Research
Published On
Jul 22, 2024
Authors
Qi-Fang Huang, De-Wei An, Lucas S. Aparicio, Yi-Bang Cheng, Fang-Fei Wei, Yu-Ling Yu, Chang-Sheng Sheng, Wen-Yi Yang, Teemu J. Niiranen, José Boggia, Katarzyna Stolarz-Skrzypek, Valérie Tikhonoff, Natasza Gilis-Malinowska, Wiktoria Wojciechowska, Edoardo Casiglia, Krzysztof Narkiewicz, Jan Filipovský, Kalina Kawecka-Jaszcz, Tim S. Nawrot, Ji-Guang Wang, Yan Li, Jan A. Staessen
Tags
pulse pressure amplification
cardiovascular risk
meta-analysis
hazard ratios
women's health
age factor

Related Publications

Explore these studies to deepen your understanding of the subject.

An epifluidic electronic patch with spiking sweat clearance for event-driven perspiration monitoring
Engineering and Technology

An epifluidic electronic patch with spiking sweat clearance for event-driven perspiration monitoring

S. Kim, S. Park, et al.

Stretchable and anti-impact iontronic pressure sensor with an ultrabroad linear range for biophysical monitoring and deep learning-aided knee rehabilitation
Engineering and Technology

Stretchable and anti-impact iontronic pressure sensor with an ultrabroad linear range for biophysical monitoring and deep learning-aided knee rehabilitation

H. Xu, L. Gao, et al.

Memory-driven capture occurs for individual features of an object
Psychology

Memory-driven capture occurs for individual features of an object

E. Sasin and D. Fougnie

Digital Disease Surveillance for Emerging Infectious Diseases: An Early Warning System Using the Internet and Social Media Data for COVID-19 Forecasting in Canada
Medicine and Health

Digital Disease Surveillance for Emerging Infectious Diseases: An Early Warning System Using the Internet and Social Media Data for COVID-19 Forecasting in Canada

Y. Yang, S. Tsao, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny