This paper presents a new mathematical model that integrates the circadian clock and drug metabolism network to determine toxicity profiles for a given drug and cell type in colorectal cancer. The model incorporates external Zeitgebers (e.g., light) to fine-tune toxicity and potentially personalize treatment schedules by aligning drug exposure with a patient's circadian rhythms.
Publisher
npj Systems Biology and Applications
Published On
Jun 23, 2023
Authors
Janina Hesse, Tim Müller, Angela Relógio
Tags
circadian clock
drug metabolism
toxicity profiles
colorectal cancer
personalized treatment
Zeitgebers
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