Engineering and Technology

An end-to-end pipeline for succinic acid production at an industrially relevant scale using Issatchenkia orientalis

V. G. Tran, S. Mishra, et al.

Discover how researchers engineered the acid-tolerant yeast *Issatchenkia orientalis* for high-yield microbial production of succinic acid at low pH, achieving titers that could change the game in organic acid production while minimizing greenhouse gas emissions. This groundbreaking research was conducted by Vinh G. Tran, Somesh Mishra, Sarang S. Bhagwat, Saman Shafaei, Yihui Shen, Jayne L. Allen, Benjamin A. Crosly, Shih-I Tan, Zia Fatma, Joshua D. Rabinowitz, Jeremy S. Guest, Vijay Singh, and Huimin Zhao.