An electric molecular motor

Macroscopic electric motors continue to have a large impact on almost every aspect of modern society. Consequently, the effort towards developing molecular motors that can be driven by electricity could not be more timely. Here we describe an electric molecular motor based on a [3]catenane, in which two cyclobis(paraquat-p-phenylene) (CBPQT4+) rings are powered by electricity in solution to circumrotate unidirectionally around a 50-membered loop. The constitution of the loop ensures that both rings undergo highly (85%) unidirectional movement under the guidance of a flashing energy ratchet, whereas the interactions between the two rings give rise to a two-dimensional potential energy surface similar to that shown by F0F1-ATP synthase. The unidirectionality is powered by an oscillating voltage or external modulation of the redox potential. Initially, we focused our attention on the homologous [2]catenane, only to find that the kinetic asymmetry was insufficient to support unidirectional movement of the sole ring. Accordingly, we incorporated a second CBPQT4+ ring to provide further symmetry breaking by interactions between the two mobile rings. This demonstration of electrically driven continual circumrotatory motion of two rings around a loop in a [3]catenane is free from the production of waste products and represents an important step towards surface-bound electric molecular motors.

Long Zhang, Yunyan Qiu, Wei-Guang Liu, Hongliang Chen, Dengke Shen, Bo Song, Kang Cai, Huang Wu, Yang Jiao, Yuanning Feng, James S. W. Seale, Cristian Pezzato, Jia Tian, Yu Tan, Xiao-Yang Chen, Qing-Hui Guo, Charlotte L. Stern, Douglas Philp, R. Dean Astumian, William A. Goddard III, J. Fraser Stoddart