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Alteration of NMDA receptor trafficking as a cellular hallmark of psychosis

Psychology

Alteration of NMDA receptor trafficking as a cellular hallmark of psychosis

A. Espana, H. Seth, et al.

This research by Agnès Espana and colleagues investigates how dysfunctions in NMDAR trafficking contribute to psychotic disorders like schizophrenia. By examining multiple models, the study reveals consistent alterations in hippocampal neurons and opens new therapeutic avenues through manipulations of NMDAR surface dynamics.

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Playback language: English
Abstract
A dysfunction of the glutamatergic transmission, especially of the NMDA receptor (NMDAR), constitutes one of the main biological substrates of psychotic disorders, such as schizophrenia. The study compared NMDAR membrane trafficking in three schizophrenia models: patient cerebrospinal fluids, genetic manipulations of susceptibility genes, and prenatal developmental alterations. Results consistently showed altered NMDAR trafficking in hippocampal neurons across all models. Manipulating NMDAR surface dynamics compensated for early pathological challenges, suggesting new therapeutic avenues.
Publisher
Translational Psychiatry
Published On
Aug 30, 2021
Authors
Agnès Espana, Henrik Seth, Julie Jézéquel, Tingting Huang, Delphine Bouchet, Marylin Lepleux, Hélène Gréa, Karl Bechter, Marion Schneider, Eric Hanse, Laurent Groc
Tags
NMDAR
schizophrenia
glutamatergic transmission
hippocampal neurons
therapeutic avenues
membrane trafficking

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