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Age-dependent impact of two exercise training regimens on genomic and metabolic remodeling in skeletal muscle and liver of male mice

Health and Fitness

Age-dependent impact of two exercise training regimens on genomic and metabolic remodeling in skeletal muscle and liver of male mice

M. Bernier, I. N. Enamorado, et al.

This groundbreaking study led by Michel Bernier and colleagues explores how age and different exercise training regimens, like HIIT and MICT, affect genomic and metabolic changes in male mice. Discover how older mice benefited from moderate training, enhancing body composition and muscle strength while unveiling the age-dependent adaptations in skeletal muscle. A tailored exercise approach for the elderly could be on the horizon!

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Playback language: English
Abstract
This study investigated the impact of age and two exercise training regimens (high-intensity intermittent training (HIIT) and moderate-intensity continuous training (MICT)) on genomic and metabolic remodeling in skeletal muscle and liver of male mice. Older mice in the MICT group showed improvements in body composition, blood glucose, and muscle strength. Both regimens induced skeletal muscle adaptations, but transcriptomics and metabolomics analyses revealed age-dependent metabolic remodeling in response to training, supporting a tailored exercise approach for the elderly.
Publisher
npj Aging
Published On
Jun 27, 2022
Authors
Michel Bernier, Ignacio Navas Enamorado, Mari Carmen Gómez-Cabrera, Miguel Calvo-Rubio, Jose Antonio González-Reyes, Nathan L. Price, Ana Belén Cortés-Rodríguez, Juan Carlos Rodríguez-Aguilera, Sandra Rodríguez-López, Sarah J. Mitchell, Kelsey N. Murt, Krystle Kalafut, Katrina M. Williams, Christopher W. Ward, Joseph P. Stains, Gloria Brea-Calvo, Jose M. Villalba, Sonia Cortassa, Miguel A. Aon, Rafael de Cabo
Tags
exercise training
age-dependent
skeletal muscle
metabolic remodeling
HIIT
MICT
male mice

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