logo
ResearchBunny Logo
Adipocyte death triggers a pro-inflammatory response and induces metabolic activation of resident macrophages

Medicine and Health

Adipocyte death triggers a pro-inflammatory response and induces metabolic activation of resident macrophages

A. Lindhorst, N. Raulien, et al.

This groundbreaking study by Andreas Lindhorst, Nora Raulien, and colleagues explores the formation of crown-like structures in adipose tissue and reveals how adipocyte death sparks a pro-inflammatory response in macrophages. Discover the metabolic activation and changes in lipid metabolism that may link obesity to inflammation.

00:00
00:00
Playback language: English
Abstract
This study investigated the dynamics of crown-like structures (CLS) in adipose tissue and their impact on adipose tissue macrophages (ATMs). Using a laser injury model in double reporter mice, the researchers tracked ATM-adipocyte interactions and CLS formation after adipocyte death. Results showed metabolic activation and increased lipid metabolism in ATMs within CLS. Adipocyte death, even in lean mice, triggered localized inflammation due to adipocyte size exceeding the threshold for efficient efferocytosis. Parabiotic mouse experiments confirmed that adipocyte death induces a pro-inflammatory response from resident ATMs without significant monocyte recruitment. The findings suggest that adipocyte death initiates a unique degradation process, leading to a metabolically activated ATM phenotype observed in obesity.
Publisher
Cell Death and Disease
Published On
Jun 05, 2021
Authors
Andreas Lindhorst, Nora Raulien, Peter Wieghofer, Jens Eilers, Fabio M. V. Rossi, Ingo Bechmann, Martin Gericke
Tags
adipose tissue
macrophages
inflammation
metabolism
adipocyte death
crown-like structures

Related Publications

Explore these studies to deepen your understanding of the subject.

Gut microbiota determines the social behavior of mice and induces metabolic and inflammatory changes in their adipose tissue
Biology

Gut microbiota determines the social behavior of mice and induces metabolic and inflammatory changes in their adipose tissue

O. Agranyomi, S. Meininger-mordechaï, et al.

The effects of omega 3 fatty acids on the serum concentrations of pro inflammatory cytokines and depression status in patients with bipolar disorder: A randomized double-blind controlled clinical trial
Medicine and Health

The effects of omega 3 fatty acids on the serum concentrations of pro inflammatory cytokines and depression status in patients with bipolar disorder: A randomized double-blind controlled clinical trial

H. Eslahi, M. Shakiba, et al.

Consumption of a high energy density diet triggers microbiota dysbiosis, hepatic lipidosis, and microglia activation in the nucleus of the solitary tract in rats
Veterinary Science

Consumption of a high energy density diet triggers microbiota dysbiosis, hepatic lipidosis, and microglia activation in the nucleus of the solitary tract in rats

D. M. Minaya, A. Turlej, et al.

Efficacy of early PET-CT directed switch to carboplatin and paclitaxel based definitive chemoradiotherapy in patients with oesophageal cancer who have a poor early response to induction cisplatin and capecitabine in the UK: a multi-centre randomised controlled phase II trial
Medicine and Health

Efficacy of early PET-CT directed switch to carboplatin and paclitaxel based definitive chemoradiotherapy in patients with oesophageal cancer who have a poor early response to induction cisplatin and capecitabine in the UK: a multi-centre randomised controlled phase II trial

S. Mukherjee, C. N. Hurt, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny