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Abstract
This study investigated the effects of rhythmic 40 Hz light flicker stimulation on social novelty deficits in female mice with a 16p11.2 deletion, a genetic risk factor for autism spectrum disorder (ASD). Long-term 40 Hz light stimulation ameliorated these deficits, reducing elevated prefrontal cortex (PFC) local field potential (LFP) power. Mechanistically, the 40 Hz light evoked adenosine release in the PFC, which, acting through A₁ receptors, suppressed excessive excitatory neurotransmission. Blocking A₁ receptors abolished the beneficial effects of the light stimulation. The findings suggest that 40 Hz light stimulation may be a promising non-invasive ASD therapeutic.
Publisher
Molecular Psychiatry
Published On
May 13, 2024
Authors
Jun Ju, Xuanyi Li, Yifan Pan, Jun Du, Xinyi Yang, Siqi Men, Bo Liu, Zhenyu Zhang, Haolin Zhong, Jinyuan Mai, Yizheng Wang, Sheng-Tao Hou
Tags
40 Hz light flicker
autism spectrum disorder
social novelty deficits
prefrontal cortex
adenosine release
A₁ receptors

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