Medicine and HealtheLife
Activity-dependent synapse elimination requires caspase-3 activation
Z. Yu, A. Gutu, et al.
During development, weak synapses are selectively removed in an activity-dependent manner — this study shows that inhibiting synaptic transmission triggers postsynaptic caspase-3 activation. Caspase-3 deficiency impairs both spontaneous and experience-dependent synapse elimination, reduces microglial engulfment of inactive synapses, and protects against amyloid-β–induced synapse loss in an Alzheimer's model. Research conducted by Zhou Yu, Andrian Gutu, Namsoo Kim, and Erin K O'Shea.
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