BiologyPNAS
A synapse-specific refractory period for plasticity at individual dendritic spines
J. C. Flores, D. Sarkar, et al.
Synapses that were recently potentiated enter a local, synapse-specific refractory period that limits further strengthening—linked to reduced postsynaptic CaMKII signaling and only partially overcome by stronger activation—until about one hour later when key postsynaptic proteins, like PSD95, return to baseline. Research conducted by Juan C. Flores, Dipannita Sarkar, and Karen Zito.
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