Psychology

A stable and replicable neural signature of lifespan adversity in the adult brain

N. E. Holz, M. Zabihi, et al.

This groundbreaking research unveils the significant impact of environmental adversities on brain structure and the development of psychiatric disorders. The study identifies a persistent neurobiological signature that persists into adulthood, highlighting the importance of individual-level predictions in understanding emerging psychopathology. Conducted by a distinguished team of authors including Nathalie E. Holz, Mariam Zabihi, and Adrian Meyer-Lindenberg.

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Abstract

Environmental adversities constitute potent risk factors for psychiatric disorders. This study estimated normative models of structural brain development based on a lifespan adversity profile in a longitudinal at-risk cohort. This revealed widespread morphometric changes in the brain, with partially adversity-specific features. This pattern was replicated in independent samples. At the individual level, greater volume contractions relative to the model were predictive of future anxiety. A stable neurobiological signature of adversity persists into adulthood, emphasizing the importance of individual-level predictions to explain emerging psychopathology.

Publisher

Nature Neuroscience

Published On

Sep 01, 2023

Authors

Nathalie E. Holz, Mariam Zabihi, Seyed Mostafa Kia, Maximillian Monninger, Pascal-M. Aggensteiner, Sebastian Siehl, Dorothea L. Floris, Arun L. W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Andreas Meyer-Lindenberg, Daniel Brandeis, Jan K. Buitelaar, Frauke Nees, Christian Beckmann, IMAGEN Consortium, Tobias Banaschewski, Andre F. Marquand

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