Environmental adversities constitute potent risk factors for psychiatric disorders. This study estimated normative models of structural brain development based on a lifespan adversity profile in a longitudinal at-risk cohort. This revealed widespread morphometric changes in the brain, with partially adversity-specific features. This pattern was replicated in independent samples. At the individual level, greater volume contractions relative to the model were predictive of future anxiety. A stable neurobiological signature of adversity persists into adulthood, emphasizing the importance of individual-level predictions to explain emerging psychopathology.
Publisher
Nature Neuroscience
Published On
Sep 01, 2023
Authors
Nathalie E. Holz, Mariam Zabihi, Seyed Mostafa Kia, Maximillian Monninger, Pascal-M. Aggensteiner, Sebastian Siehl, Dorothea L. Floris, Arun L. W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Andreas Meyer-Lindenberg, Daniel Brandeis, Jan K. Buitelaar, Frauke Nees, Christian Beckmann, IMAGEN Consortium, Tobias Banaschewski, Andre F. Marquand
Tags
environmental adversities
psychiatric disorders
structural brain development
morphometric changes
anxiety
neurobiological signature
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