Psychology

A specific neural substrate predicting current and future impulsivity in young adults

J. S. Steele, M. Bertocci, et al.

This groundbreaking research conducted by J. Scott Steele and colleagues uncovers specific neural markers of impulsivity in young adults. By examining amygdala and prefrontal cortex activity during facial fear processing, the study reveals that heightened amygdala activity is linked to increased impulsivity. These findings could revolutionize interventions for mental health issues related to impulsivity.

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Abstract

Impulsivity, a common feature in many psychiatric disorders, is investigated in this study to identify specific neural markers. Researchers examined amygdala-prefrontal cortex (PFC) activity and functional connectivity in a large, transdiagnostic sample of young adults (N=114). Impulsivity, especially negative urgency and lack of perseverance, correlated with increased amygdala activity and reduced amygdala-medial PFC connectivity during facial fear processing. Amygdala activity to facial sadness predicted future impulsivity worsening. These findings suggest specific neural targets for interventions aimed at reducing impulsivity and related mental health problems.

Publisher

Molecular Psychiatry

Published On

Jan 25, 2021

Authors

J. Scott Steele, Michele Bertocci, Kristen Eckstrand, Henry W. Chase, Richelle Stiffler, Haris Aslam, Jeanette Lockovich, Genna Bebko, Mary L. Phillips

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