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A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models

Medicine and Health

A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models

F. Ren, A. Aliper, et al.

This groundbreaking research identifies TRAF2-and NCK-interacting kinase (TNIK) as an anti-fibrotic target for idiopathic pulmonary fibrosis (IPF). Utilizing artificial intelligence, the study introduces INS018_055, a small-molecule TNIK inhibitor that demonstrates significant anti-fibrotic and anti-inflammatory effects in vivo. With successful Phase I clinical trials confirming safety and tolerability, this work by esteemed authors paves the way for AI-driven advancements in drug discovery.

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