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A region-confined PROTAC nanoplatform for spatiotemporally tunable protein degradation and enhanced cancer therapy
Medicine and HealthNature Communications

A region-confined PROTAC nanoplatform for spatiotemporally tunable protein degradation and enhanced cancer therapy

J. Gao, X. Jiang, et al.

This groundbreaking research by Jing Gao and colleagues introduces a novel PROTAC nanoplatform that overcomes traditional limitations in tumor specificity and pharmacokinetics. By integrating ROS-activatable and hypoxia-responsive components, this innovative strategy targets tumor cells effectively, improving drug release under specific conditions and leading to enhanced tumor eradication.... show more
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