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A Randomized Controlled Study Assessing Convalescent Immunoglobulins vs Convalescent Plasma for Hospitalized Patients With Coronavirus 2019

Medicine and Health

A Randomized Controlled Study Assessing Convalescent Immunoglobulins vs Convalescent Plasma for Hospitalized Patients With Coronavirus 2019

Y. Maor, E. Shinar, et al.

This study reveals that convalescent immunoglobulins (cIgGs) may be a promising treatment for high-risk hospitalized COVID-19 patients, especially among the unvaccinated, showcasing significant survival benefits at day 28. Conducted by a team of experts, including Yasmin Maor and Galia Rahav, this trial provides critical insights into effective strategies for managing COVID-19 as new variants emerge.

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Playback language: English
Abstract
This randomized controlled trial compared convalescent immunoglobulins (cIgGs) and convalescent plasma (CP) for treating high-risk hospitalized COVID-19 patients. The primary endpoint (WHO scale improvement at day 14) showed no noninferiority of cIgGs to CP. However, secondary endpoints revealed superior improvement at day 28 with cIgGs, particularly in unvaccinated patients, who also showed better survival. cIgGs offer a viable treatment option, especially considering the emergence of new variants.
Publisher
Clinical Infectious Diseases
Published On
May 23, 2023
Authors
Yasmin Maor, Eilat Shinar, Marina Izak, Galia Rahav, Tal Brosh-Nissimov, Asa Kessler, Naomi Rahimi-Levene, Odeda Benin-Goren, Dani Cohen, Iris Zohar, Noga Alagem, Sharon Castro, Oren Zimhony
Tags
COVID-19
convalescent immunoglobulins
convalescent plasma
treatment
hospitalized patients
vaccination
survival

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