This in vivo study investigated the potential of a novel oleogel-based probiotic formulation for treating diabetic ulcers (DUs). Four Lactobacillus species (*L. rhamnosus*, *L. casei*, *L. fermentum*, and *L. acidophilus*) were individually incorporated into the formulation. *L. acidophilus* and *L. rhamnosus* demonstrated the most significant wound-healing potential, exhibiting increased hydroxyproline content, fibroblast density, collagen fibrils, and neovascularization compared to tetracycline and control groups. *L. rhamnosus* also showed significant biofilm inhibition activity against common pathogens. The findings suggest this probiotic formulation, particularly those containing *L. acidophilus* and *L. rhamnosus*, holds promise as an alternative treatment for DUs, warranting further clinical trials.
Publisher
Nutrition and Diabetes
Published On
Aug 20, 2024
Authors
Farkhonde Karimi, Nima Montazeri-Najafabady, Fatemeh Mohammadi, Amir Azadi, Farhad Koohpeyma, Ahmad Gholami
Tags
diabetic ulcers
probiotic formulation
oleogel
Lactobacillus
wound healing
biofilm inhibition
clinical trials
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