A novel genomic region on chromosome 11 associated with fearfulness in dogs

Veterinary Science

A novel genomic region on chromosome 11 associated with fearfulness in dogs

R. Sarviaho, O. Hakosalo, et al.

This groundbreaking study, conducted by R. Sarviaho and colleagues, uncovers the genetic basis of fearfulness in Great Dane dogs. Through a genome-wide association study, the researchers identified a significant locus on chromosome 11 linked to fear, with candidate genes like MAPK9/JNK2. This research not only sheds light on canine anxiety but also serves as a promising model for understanding human anxiety disorders.

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Playback language: English
Abstract
This study investigated the genetic basis of fearfulness in Great Dane dogs. Using a validated behavioral survey, 124 dogs were categorized into cases (fearful) and controls (non-fearful). A genome-wide association study (GWAS), incorporating socialization as a covariate, revealed a significant locus on chromosome 11. Whole exome and genome sequencing identified regions of contrasting homozygosity in this locus, highlighting candidate genes such as *MAPK9/JNK2*, a hippocampal anxiety regulator. This discovery provides insights into the molecular basis of fear in dogs and offers a potential animal model for human anxiety disorders.
Publisher
Translational Psychiatry
Published On
Jan 31, 2020
Authors
R. Sarviaho, O. Hakosalo, K. Tiira, S. Sulkama, J. E. Niskanen, M. K. Hytönen, M. J. Sillanpää, H. Lohi
Tags
Great Dane
fearfulness
genome-wide association study
candidate genes
anxiety disorders

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