A novel genomic region on chromosome 11 associated with | ResearchBunny

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Abstract

This study investigated the genetic basis of fearfulness in Great Dane dogs. Using a validated behavioral survey, 124 dogs were categorized into cases (fearful) and controls (non-fearful). A genome-wide association study (GWAS), incorporating socialization as a covariate, revealed a significant locus on chromosome 11. Whole exome and genome sequencing identified regions of contrasting homozygosity in this locus, highlighting candidate genes such as *MAPK9/JNK2*, a hippocampal anxiety regulator. This discovery provides insights into the molecular basis of fear in dogs and offers a potential animal model for human anxiety disorders.

Publisher

Translational Psychiatry

Published On

Jan 31, 2020

Authors

R. Sarviaho, O. Hakosalo, K. Tiira, S. Sulkama, J. E. Niskanen, M. K. Hytönen, M. J. Sillanpää, H. Lohi

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