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Abstract
This study demonstrates a negative feedback loop between TET2 and leptin in adipocytes, regulating body weight. Leptin, via JAK2-STAT3 signaling, suppresses adipocyte TET2 levels. Adipocyte Tet2 deficiency protects against high-fat diet-induced weight gain by reducing leptin and improving leptin sensitivity. Adipocyte TET2, interacting with C/EBPa, increases leptin gene expression. Decreased adipose TET2 correlates with obesity-related hyperleptinemia in humans. Inhibition of TET2 suppresses leptin production in human adipocytes.
Publisher
Nature Communications
Published On
Apr 01, 2024
Authors
Qin Zeng, Jianfeng Song, Xiaoxiao Sun, Dandan Wang, Xiyan Liao, Yujin Ding, Wanyu Hu, Yayi Jiao, Wuqian Mai, Wufuer Aini, Fanqi Wang, Hui Zhou, Limin Xie, Ying Mei, Yuan Tang, Zhiguo Xie, Haijing Wu, Wei Liu, Tuo Deng
Tags
TET2
leptin
adipocytes
body weight
obesity
diet
hyperleptinemia

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