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A mid-infrared lab-on-a-chip for dynamic reaction monitoring

Engineering and Technology

A mid-infrared lab-on-a-chip for dynamic reaction monitoring

B. Hinkov, F. Pilat, et al.

Discover groundbreaking advancements in real-time molecular dynamics monitoring with a chip-scale sensor developed by Borislav Hinkov and colleagues. Utilizing innovative quantum cascade technology, this integrated device allows for precise in situ measurements of microliter samples, showcasing remarkable linearity and a wide concentration range while outshining traditional bulky systems.

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Playback language: English
Abstract
This work presents a fully integrated, chip-scale sensor for real-time monitoring of molecular dynamics in liquid solutions. Utilizing quantum cascade technology, the device combines emitter, sensing section, and detector on a single chip, enabling in situ measurements of microliter samples. The sensor's performance is demonstrated by analyzing temperature-induced conformational changes in bovine serum albumin, showing excellent linearity, a wide concentration range (0.075 mg ml⁻¹ to 92 mg ml⁻¹), and significantly higher absorbance compared to bulky reference systems.
Publisher
Nature Communications
Published On
Aug 13, 2022
Authors
Borislav Hinkov, Florian Pilat, Laurin Lux, Patricia L. Souza, Mauro David, Andreas Schwaighofer, Daniela Ristanić, Benedikt Schwarz, Hermann Detz, Aaron M. Andrews, Bernhard Lendl, Gottfried Strasser
Tags
chip-scale sensor
molecular dynamics
quantum cascade technology
real-time monitoring
bovine serum albumin
conformational changes

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