This work presents a fully integrated, chip-scale sensor for real-time monitoring of molecular dynamics in liquid solutions. Utilizing quantum cascade technology, the device combines emitter, sensing section, and detector on a single chip, enabling in situ measurements of microliter samples. The sensor's performance is demonstrated by analyzing temperature-induced conformational changes in bovine serum albumin, showing excellent linearity, a wide concentration range (0.075 mg ml⁻¹ to 92 mg ml⁻¹), and significantly higher absorbance compared to bulky reference systems.
Publisher
Nature Communications
Published On
Aug 13, 2022
Authors
Borislav Hinkov, Florian Pilat, Laurin Lux, Patricia L. Souza, Mauro David, Andreas Schwaighofer, Daniela Ristanić, Benedikt Schwarz, Hermann Detz, Aaron M. Andrews, Bernhard Lendl, Gottfried Strasser
Tags
chip-scale sensor
molecular dynamics
quantum cascade technology
real-time monitoring
bovine serum albumin
conformational changes
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