Engineering and Technology

A hybrid transistor with transcriptionally controlled computation and plasticity

Y. Gao, Y. Zhou, et al.

Discover the potential of organic electrochemical transistors (OECTs) in bioelectronics! This innovative research by Yang Gao, Yuchen Zhou, Xudong Ji, and colleagues showcases hybrid OECTs that integrate the bacterium *Shewanella oneidensis*, translating biological computations into electrical signals. The study reveals how extracellular electron transfer can control channel de-doping, paving the way for advanced biosensing and biocomputing systems.

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Abstract

Organic electrochemical transistors (OECTs) are promising devices for bioelectronics due to their compatibility with biological systems. This paper describes hybrid OECTs incorporating the bacterium *Shewanella oneidensis*, enabling the transduction of biological computations into electrical responses. The authors demonstrate that channel de-doping is driven by extracellular electron transfer (EET) from *S. oneidensis*, controllable via transcriptional regulation. Boolean logic gates were used to translate biological computation into current changes, and EET-driven synaptic plasticity was also demonstrated. This work advances fundamental EET studies and creates genetically controllable, modular biosensing and biocomputing systems.

Publisher

Nature Communications

Published On

Feb 21, 2024

Authors

Yang Gao, Yuchen Zhou, Xudong Ji, Austin J. Graham, Christopher M. Dundas, Ismar E. Miniel Mahfoud, Bailey M. Tibbett, Benjamin Tan, Gina Partipilo, Ananth Dodabalapur, Jonathan Rivnay, Benjamin K. Keitz

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