Organic electrochemical transistors (OECTs) are promising devices for bioelectronics due to their compatibility with biological systems. This paper describes hybrid OECTs incorporating the bacterium *Shewanella oneidensis*, enabling the transduction of biological computations into electrical responses. The authors demonstrate that channel de-doping is driven by extracellular electron transfer (EET) from *S. oneidensis*, controllable via transcriptional regulation. Boolean logic gates were used to translate biological computation into current changes, and EET-driven synaptic plasticity was also demonstrated. This work advances fundamental EET studies and creates genetically controllable, modular biosensing and biocomputing systems.
Publisher
Nature Communications
Published On
Feb 21, 2024
Authors
Yang Gao, Yuchen Zhou, Xudong Ji, Austin J. Graham, Christopher M. Dundas, Ismar E. Miniel Mahfoud, Bailey M. Tibbett, Benjamin Tan, Gina Partipilo, Ananth Dodabalapur, Jonathan Rivnay, Benjamin K. Keitz
Tags
Organic electrochemical transistors
Bioelectronics
Extracellular electron transfer
Biological computation
Biosensing
Modular systems
Hybrid devices
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