Medicine and HealthNature
A high-performance speech neuroprosthesis
F. R. Willett, E. M. Kunz, et al.
Intracortical microelectrode arrays decoded attempted speech from a participant with ALS, achieving a 9.1% WER on a 50-word vocabulary and 23.8% WER on a 125,000-word vocabulary—the first large‑vocabulary demonstration—at 62 words per minute, nearing conversational speed. The study also reveals spatially intermixed articulator tuning and persistent phoneme representations. Research conducted by Francis R. Willett, Erin M. Kunz, Chaofei Fan, Donald T. Avansino, Guy H. Wilson, Eun Young Choi, Foram Kamdar, Matthew F. Glasser, Leigh R. Hochberg, Shaul Druckmann, Krishna V. Shenoy, and Jaimie M. Henderson.
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