Chemistry

A concise and scalable chemoenzymatic synthesis of prostaglandins

Y. Yin, J. Wang, et al.

This innovative report reveals a streamlined chemoenzymatic method for synthesizing prostaglandins in just 5 to 7 steps. With a focus on high enantioselectivity and economical lipid chain incorporation, this research led by Yunpeng Yin, Jinxin Wang, and Jian Li promises to make prostaglandin-related drugs more accessible and affordable.

00:00

Playback language: English

Index

Abstract

This report presents a concise chemoenzymatic synthesis method for several representative prostaglandins, achieved in 5 to 7 steps. A common intermediate, bromohydrin (a radical equivalent of Corey lactone), is chemoenzymatically synthesized in two steps, enabling a five-step synthesis of prostaglandin F<sub>2α</sub> on a 10-gram scale. The synthesis features high enantioselectivity and cost-effective incorporation of lipid chains via bromohydrin formation, nickel-catalyzed cross-couplings, and Wittig reactions. This efficient route has the potential to make prostaglandin-related drugs more affordable.

Publisher

Nature Communications

Published On

Mar 21, 2024

Authors

Yunpeng Yin, Jinxin Wang, Jian Li

Related Publications

Explore these studies to deepen your understanding of the subject.

Chemistry

A general strategy for heterogenizing olefin polymerization catalysts and the synthesis of polyolefins and composites

C. Zou, G. Si, et al.

Chemistry

Discovering and harnessing oxidative enzymes for chemoenzymatic synthesis and diversification of anticancer camptothecin analogues

T. M. Nguyen, T. Nguyen, et al.

Political Science

A synthesis of Kantian ethics and Rousseauvian General Will in justifying the moral ground of political laws

S. Lin

Medicine and Health

Effects of vitamin D supplementation on cardiometabolic parameters among patients with metabolic syndrome: A systematic review and GRADE evidence synthesis of randomized controlled trials

S. Aquino, A. Cunha, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny