Discovering and harnessing oxidative enzymes for chemoenzymatic | ResearchBunny

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Abstract

This research discovered two cytochrome P450 monooxygenases from *Camptotheca acuminata* that catalyze the regio-specific oxidation of camptothecin. These enzymes were used in combinatorial chemoenzymatic C-H functionalizations to produce various anticancer drugs, including topotecan and irinotecan. This work provides insights into camptothecin metabolism and offers greener approaches for producing clinically relevant derivatives.

Publisher

Communications Chemistry

Published On

Dec 16, 2021

Authors

Tuan-Anh M. Nguyen, Trinh-Don Nguyen, Yuen Yee Leung, Matthew McConnachie, Oleg Sannikov, Zhicheng Xia, Thu-Thuy T. Dang

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