A combined GWAS approach reveals key loci for socially-affected traits in Yorkshire pigs

This study investigated the genetic basis of direct genetic effects (DGE) and social genetic effects (SGE) on socially affected traits in Yorkshire pigs using a combined single-locus and haplotype-based genome-wide association study (GWAS) on imputed whole-genome sequences. The analysis identified several significant SNPs and haplotype loci associated with DGE and SGE for traits like average daily feed intake, average daily gain, days to 100 kg, and time in feeder per day. The MT3 gene, involved in growth and other processes, was identified as a candidate gene. The study demonstrates genetic differences between DGE and SGE and provides insights into the genetic architecture of socially affected traits.

Pingxian Wu, Kai Wang, Jie Zhou, Dejuan Chen, Anan Jiang, Yanzhi Jiang, Li Zhu, Xiaotian Qiu, Xuewei Li, Guoqing Tang