Medicine and Health

Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron

H. Ma, X. Zhang, et al.

This groundbreaking study reveals two hetero-bivalent nanobodies that effectively neutralize various SARS-CoV-2 variants, including Omicron. Researchers, including Huan Ma, Xinghai Zhang, and Peiyi Zheng, highlight the potential of aRBD-2-5-Fc for COVID-19 prevention and treatment, demonstrating significant protection in hamsters.

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Index

Abstract

The emergence of SARS-CoV-2 variants with adaptive mutations necessitates the development of broad-spectrum antivirals. This study investigated two hetero-bivalent nanobodies (Nbs), aRBD-2-5 and aRBD-2-7, previously shown to neutralize wild-type SARS-CoV-2. Crystal structures revealed that aRBD-2 binds to conserved RBD residues, maintaining binding to various variants including Omicron. Fusion with aRBD-5 or aRBD-7 enhanced binding affinity. Both aRBD-2-5-Fc and aRBD-2-7-Fc potently neutralized multiple variants *in vitro*. aRBD-2-5-Fc demonstrated prophylactic and therapeutic protection against Omicron BA.1 in hamsters, suggesting its potential for COVID-19 prevention and treatment.

Publisher

Cell Research

Published On

Jul 29, 2022

Authors

Huan Ma, Xinghai Zhang, Peiyi Zheng, Peter H. Dube, Weihong Zeng, Shaohong Chen, Qingyu Cheng, Yunru Yang, Yan Wu, Junhui Zhou, Xiaowen Hu, Yan Xiang, Huajun Zhang, Sandra Chiu, Tengchuan Jin

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