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3D free-assembly modular microfluidics inspired by movable type printing

Engineering and Technology

3D free-assembly modular microfluidics inspired by movable type printing

S. Huang, J. Wu, et al.

This groundbreaking research presents a novel 3D free-assembly modular microfluidics scheme, inspired by movable type printing. It features rapid prototyping and small batch production of disposable microfluidic chips, enabling advanced applications like concentration gradient generation and drug screening, all developed by a team from the University of Shanghai for Science and Technology and the Shenzhen Institute of Advanced Technology.

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Playback language: English
Abstract
This paper proposes a novel manufacturing scheme for 3D free-assembly modular microfluidics (3D-FAMM), inspired by movable type printing. The method involves creating a library of modularized molds for various microfluidic functions (flow control, droplet manipulation, cell trapping) and attachments (valves, light sources, cameras). These modules are assembled to create double-layer 3D microfluidic structures replicated using PDMS. The system allows for rapid prototyping and small batch production of disposable microfluidic chips, demonstrated through applications such as concentration gradient generation, droplet-based microfluidics, cell trapping, and drug screening.
Publisher
Microsystems & Nanoengineering
Published On
Jul 26, 2023
Authors
Shaoqi Huang, Jiandong Wu, Lulu Zheng, Yan Long, Junyi Chen, Jianlang Li, Bo Dai, Francis Lin, Songlin Zhuang, Dawei Zhang
Tags
microfluidics
3D printing
prototyping
modular design
drug screening
cell trapping

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