Veterinary Science

Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits

X. Li, J. Yang, et al.

This study unveils the genetic underpinnings of phenotypic variation in sheep by deeply resequencing 248 individuals, including wild ancestors and improved breeds. The findings highlight crucial genomic regions related to distinct traits and suggest *PDGFD* as a key gene influencing tail fat deposition. Conducted by a collaborative team of experts, this research is a pivotal contribution to sheep breeding and genetic study.

00:00

Playback language: English

Index

Abstract

Understanding the genetic changes underlying phenotypic variation in sheep (*Ovis aries*) may facilitate our efforts towards further improvement. This study reports the deep resequencing of 248 sheep including the wild ancestor (*O. orientalis*), landraces, and improved breeds. Genomic regions harboring genes associated with distinct morphological and agronomic traits were detected. Non-synonymous mutations in candidate genes and significant differences in allele frequency distributions across breeds were found. *PDGFD* was identified as a likely causal gene for tail fat deposition. The results provide insights into sheep's demographic history and a valuable genomic resource for future genetic studies and improved genome-assisted breeding.

Publisher

Nature Communications

Published On

Jun 04, 2020

Authors

Xin Li, Ji Yang, Min Shen, Xing-Long Xie, Guang-Jian Liu, Ya-Xi Xu, Feng-Hua Lv, Hua Yang, Yong-Lin Yang, Chang-Bin Liu, Ping Zhou, Peng-Cheng Wan, Yun-Sheng Zhang, Lei Gao, Jing-Quan Yang, Wen-Hui Pi, Yan-Ling Ren, Zhi-Qiang Shen, Feng Wang, Juan Deng, Song-Song Xu, Hosein Salehian-Dehkordi, Eer Hehua, Ali Esmailizadeh, Mostafa Dehghani-Qanatqestani, Ondřej Štěpánek, Christina Weimann, Georg Erhardt, Agraw Amane, Joram M. Mwacharo, Jian-Lin Han, Olivier Hanotte, Johannes A. Lenstra, Juha Kantanen, David W. Coltman, James W. Kijas, Michael W. Bruford, Kathiravan Periasamy, Xin-Hua Wang, Meng-Hua Li

Related Publications

Explore these studies to deepen your understanding of the subject.

Medicine and Health

Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality

X. Liu, W. Yang, et al.

Medicine and Health

Comprehensive analysis of atherosclerotic plaques reveals crucial genes and molecular mechanisms associated with plaque progression and rupture

J. Wang, S. Xu, et al.

Medicine and Health

Application of deep learning algorithm on whole genome sequencing data uncovers structural variants associated with multiple mental disorders in African American patients

Y. Liu, H. Qu, et al.

Veterinary Science

Genome-wide association study to identify genomic regions and positional candidate genes associated with male fertility in beef cattle

H. Sweett, P. A. S. Fonseca, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny