This refined risk assessment evaluates the efficacy of various glove materials in mitigating hazards from N-methylpyrrolidone (NMP) in paint strippers, using USEPA's TSCA risk assessment scenarios. Three glove categories (minimal, moderate, maximal protection) were defined based on NMP permeation rates. PBPK modeling predicted peak (Cmax) and cumulative (AUC) internal NMP doses for eight acute and chronic occupational exposure scenarios. Moderate protection gloves yielded acceptable MOE values (≥30) for half of the acute scenarios, while maximal protection gloves showed acceptable MOEs for all acute and all but one chronic scenario. The study demonstrates wide variation in glove protection (PF 1.1-1900) and supports safe NMP use with appropriate PPE, suggesting risk-reduction methods as alternatives to banning NMP.
Publisher
Springer Nature
Published On
Mar 09, 2020
Authors
C. R. Kirman
Tags
N-methylpyrrolidone
glove protection
risk assessment
occupational exposure
personal protective equipment
permeation rates
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